Antibiotic use to treat catheter-associated bacteriuria futile in decreasing risk of mortality
PUBLIC RELEASE DATE:
16-Oct-2013
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Contact: Tamara Moore tmoore@gymr.com 202-745-5114 Society for Healthcare Epidemiology of America
With 30 million indwelling bladder catheters placed annually nationwide, patients face an increased risk of developing catheter-associated bacteriuria (bacteria in the urine). Many patients with indwelling urinary catheters acquire bacteria in the urinary tract while they are catheterized. Most previous studies assessing morbidity and mortality associated with catheter use have not separated urinary tract infection from asymptomatic bacteriuria. This has made it difficult to determine if bacteria in the urine puts patients at higher risk for bloodstream infection or death. The study is published in the November issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.
In a retrospective cohort study of 444 urine cultures from 308 patients, researchers at Baylor College of Medicine found that catheter-associated urinary tract infection, but not asymptomatic bacteriuria, was significantly associated with developing bacteremia (bacteria in the bloodstream) within 30 days but was not significantly associated with mortality. Treatment with antibiotics did not reduce the risk of developing bacteremia or change mortality rates. Overall mortality was high (21.1 percent), indicating, as expected, that hospitalized patients who require indwelling bladder catheters have many serious underlying illnesses.
"Our study findings call into question what we are accomplishing by treating with antibiotics bacteria that are found in urine in asymptomatic patients" said Barbara Trautner, MD, senior author of the study.
Fifty-two patients experienced bacteria in the bloodstream within a month after the urine culture was collected, but only three of these infections might have started in the urinary tract. In other words, only three of 444 positive urine cultures (less than 1%) might have led to bloodstream infection. Giving antimicrobial agents specifically to treat bacteria found in the urine did not decrease the risk of bloodstream infection or death. In spite of that, nearly 90 percent of patients (277 of 308 patients) received some antimicrobial agent for some reason, not necessarily to treat the urine, between 7 days before to 30 days after obtaining the urine culture.
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Quratulain F. Kizilbash, Nancy J. Petersen, Guoqing J. Chen, Aanand D. Naik, MD;2,3,5 Barbara W. Trautner. "Bacteremia and Mortality with Urinary Catheter-Associated Bacteriuria." Infection Control and Hospital Epidemiology 34:11 (November 2013).
Published through a partnership between the Society for Healthcare Epidemiology of America and The University of Chicago Press, Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 13 out of 158 journals in its discipline in the latest Web of Knowledge Journal Citation Reports from Thomson Reuters.
SHEA is a professional society representing more than 2,000 physicians and other healthcare professionals around the world with expertise in healthcare epidemiology and infection prevention and control. SHEA's mission is to prevent and control healthcare-associated infections and advance the field of healthcare epidemiology. The society leads this field by promoting science and research and providing high-quality education and training in epidemiologic methods and prevention strategies. SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings. Visit SHEA online at http://www.shea-online.org, http://www.facebook.com/SHEApreventingHAIs and @SHEA_Epi.
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Antibiotic use to treat catheter-associated bacteriuria futile in decreasing risk of mortality
PUBLIC RELEASE DATE:
16-Oct-2013
[
| E-mail
| Share
]
Contact: Tamara Moore tmoore@gymr.com 202-745-5114 Society for Healthcare Epidemiology of America
With 30 million indwelling bladder catheters placed annually nationwide, patients face an increased risk of developing catheter-associated bacteriuria (bacteria in the urine). Many patients with indwelling urinary catheters acquire bacteria in the urinary tract while they are catheterized. Most previous studies assessing morbidity and mortality associated with catheter use have not separated urinary tract infection from asymptomatic bacteriuria. This has made it difficult to determine if bacteria in the urine puts patients at higher risk for bloodstream infection or death. The study is published in the November issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.
In a retrospective cohort study of 444 urine cultures from 308 patients, researchers at Baylor College of Medicine found that catheter-associated urinary tract infection, but not asymptomatic bacteriuria, was significantly associated with developing bacteremia (bacteria in the bloodstream) within 30 days but was not significantly associated with mortality. Treatment with antibiotics did not reduce the risk of developing bacteremia or change mortality rates. Overall mortality was high (21.1 percent), indicating, as expected, that hospitalized patients who require indwelling bladder catheters have many serious underlying illnesses.
"Our study findings call into question what we are accomplishing by treating with antibiotics bacteria that are found in urine in asymptomatic patients" said Barbara Trautner, MD, senior author of the study.
Fifty-two patients experienced bacteria in the bloodstream within a month after the urine culture was collected, but only three of these infections might have started in the urinary tract. In other words, only three of 444 positive urine cultures (less than 1%) might have led to bloodstream infection. Giving antimicrobial agents specifically to treat bacteria found in the urine did not decrease the risk of bloodstream infection or death. In spite of that, nearly 90 percent of patients (277 of 308 patients) received some antimicrobial agent for some reason, not necessarily to treat the urine, between 7 days before to 30 days after obtaining the urine culture.
###
Quratulain F. Kizilbash, Nancy J. Petersen, Guoqing J. Chen, Aanand D. Naik, MD;2,3,5 Barbara W. Trautner. "Bacteremia and Mortality with Urinary Catheter-Associated Bacteriuria." Infection Control and Hospital Epidemiology 34:11 (November 2013).
Published through a partnership between the Society for Healthcare Epidemiology of America and The University of Chicago Press, Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 13 out of 158 journals in its discipline in the latest Web of Knowledge Journal Citation Reports from Thomson Reuters.
SHEA is a professional society representing more than 2,000 physicians and other healthcare professionals around the world with expertise in healthcare epidemiology and infection prevention and control. SHEA's mission is to prevent and control healthcare-associated infections and advance the field of healthcare epidemiology. The society leads this field by promoting science and research and providing high-quality education and training in epidemiologic methods and prevention strategies. SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings. Visit SHEA online at http://www.shea-online.org, http://www.facebook.com/SHEApreventingHAIs and @SHEA_Epi.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
The Washington Post has published new revelations about the National Security Agency's electronic snooping, indicating that the intelligence branch gathers millions of contact lists from personal email accounts and instant messaging around the world.
The new information is attributed by the Post to "senior intelligence officials and top-secret documents provided by former NSA contractor Edward Snowden."
"The collection program, which has not been disclosed before, intercepts e-mail address books and 'buddy lists' from instant messaging services as they move across global data links. Online services often transmit those contacts when a user logs on, composes a message, or synchronizes a computer or mobile device with information stored on remote servers.
Rather than targeting individual users, the NSA is gathering contact lists in large numbers that amount to a sizable fraction of the world's e-mail and instant messaging accounts. Analysis of that data enables the agency to search for hidden connections and to map relationships within a much smaller universe of foreign intelligence targets."
According to the newspaper, in a single day last year the NSA harvested 444,743 email address books from Yahoo, 105,068 from Hotmail, 82,857 from Facebook, 33,697 from Gmail and 22,881 from unspecified other providers.
The Post story quotes Yahoo as saying in response to NSA effort, it would begin encrypting user connections using SLL technology in January.
However, last month, The Two-Way's Eyder Peralta wrote that The New York Times and The Guardian, relying on documents from Snowden, revealed that the NSA has the keys to crack most Internet encryption methods.
"In plain English, this means that many of the tools — like , used by many banks and email providers — that people worldwide have come to believe protect them from snooping by criminals and governments are essentially worthless when it comes to the NSA."
Google’s quarterly sales increased again, although the company reported mixed results within its advertising business and a decrease in its Motorola mobile sales.
Revenue was $14.89 billion for the period ended Sept. 30, the company announced Thursday. That’s a 12 percent increase from the same period last year, excluding commissions and fees, or traffic acquisition costs that Google pays to other sites that run its ads. Taking those into account, the company’s sales were $11.92 billion.
Google’s net income for the quarter was $2.97 billion, a roughly 36 percent jump from the $2.18 billion reported for the third quarter last year. The company’s earnings per share were $8.75, up strongly from $6.53 last year.
“We are closing in on our goal of a beautiful, simple and intuitive experience regardless of your device,” Google CEO Larry Page said in a statement regarding the company’s progress toward addressing the shift by users to mobile devices.
Looking specifically at its advertising business, however, Google saw more mixed results. Paid clicks, or the clicks on search ads paid for by advertisers, increased by 26 percent over the third quarter of 2012, Google said, and increased by 8 percent over 2013’s second quarter. But the cost of paid clicks, or the money Google charges when someone clicks on an ad, fell by 8 percent over last year, and also decreased by 4 percent compared to this year’s second quarter, Google reported.
There was also a decrease in revenue from Motorola mobile, which includes hardware. That unit’s sales were $1.18 billion, or 8 percent of Google’s consolidated revenue—about a 33 percent drop.
Google paid more than $12 billion to buy Motorola Mobility last year. The highly anticipated Moto X smartphone, the first phone designed after the acquisition, launched in August with a focus on more user-friendly features.
Meanwhile, Google-owned sites generated revenue of $9.39 billion, a 22 percent increase over the same period last year, Google reported. The company’s partner sites contributed revenue of $3.15 billion, roughly flat compared to last year.
Zach Miners, IDG News Service , IDG News Service
Zach Miners covers social networking, search and general technology news for IDG News Service More by Zach Miners, IDG News Service
Stephen Frears' British dramedy Philomena, starring Judi Dench, has received an R rating in the U.S. from the Classification and Ratings Administration for two non-sexual uses of the f-word.
The Weinstein Co., which is releasing the critically acclaimed film over the Thanksgiving holiday, failed in its bid to be granted an exemption and will now officially appeal the rating, insiders tell THR. TWC believes the movie will appeal to a broad spectrum of moviegoers, and says an R rating will hurt that effort.
Harvey Weinstein's company is no stranger when it comes to taking issue with the ratings board, having waged high-profile appeals for The King's Speech and Bully, both of which received an R for language.
TWC has big plans for Philomena, based on the 2009 investigative book by BBC correspondent Martin Sixsmith about Philomena Lee, an Irish-Catholic woman who was forced decades earlier to put up her illegitimate baby for adoption in the U.S. The story follows Philomena (Dench) and the journalist (Steve Coogan) as they travel to the U.S. to find the child. TWC believes the film will be an awards contender.
Philomena opens in New York and Los Angeles on Nov. 22 before making a moderate nationwide push on Nov. 27, the Wednesday before Thanksgiving. Moviegoing spikes over the long holiday weekend, and TWC believes Philomena will play to families and serve as potent counterprogramming to more commercial fare.
Last year, the ratings board granted a language exemption to Bully, which also contained more than one use of the word "f---."
"It doesn't make sense why they didn't do it here. It's a wholesome movie that deserves to be seen by everybody," says one person close to the film. "It's not even Judi Dench's character who says the word."
In the U.K., Philomena received a 12 rating, meaning it is deemed suitable for anyone 12 and over.
Philomena made its world premiere in competition at the recent Venice International Film Festival, where Coogan and Jeff Pope won the award for best screenplay. The film next made its North American debut at the Toronto Film Festival.
Space may be the final frontier of exploration, but there's plenty of Earth left unmapped, too—from the giant canyon recently discovered beneath Greenland to American waters that have been left largely unexplored. But that’s quickly changing, thanks in part to Bob Ballard’s latest project.
Staying busy outside of her music career, Nicki Minaj launched her clothing collection at Kmart in Los Angeles on Tuesday (October 15).
Arriving in a pink Lamborghini, the "Starships" rapper wore a cleavage-baring blue jacket, black leggings, and white heels as she posed with her fashion line on the pink carpet.
Sharing a photograph of herself arriving in style, the 30-year-old hip-hop star tweeted, "Pulled up to Kmart like this for my press day earlier. Thanks for making it pink @exoticeurocars."
In addition to fashion and music, Nicki will soon try her hand at acting, appearing on the big screen in "The Other Woman" this spring.